Cellular biosynthesis
Gene co-expression module in CD4⁺ T cells
| Category | Housekeeping |
|---|---|
| Genes | 18 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 18 genes have a known function matching the annotation |
Why this annotation
Hub genes SMC3 (cohesin), HDGF, PSPC1, NONO-related nuclear factors, plus metabolic/biosynthetic genes (SREBF2 cholesterol, MTHFD2 one-carbon, MRPS11 mito ribosome, UROS heme). This is a mixed proliferation/biosynthesis module enriched in inflamed tissue. SMC3 (chromosome cohesion), RABL6, SAE1 (SUMO), OTUB1 (deubiquitinase) point toward a cell-growth/anabolic program. Inflammation-correlated, decreasing with treatment — consistent with activated proliferating CD4 cells. No single dominant program; growth/metabolism best fits.
Genes
CCDC32, CTSB, HDGF, MEA1, MESD, MFSD6, MRPS11, MTHFD2, NAA60, OTUB1, PSPC1, RAB11B, RABL6, SAE1, SMC3, SREBF2, UROS, VOPP1
Most correlated modules
- Vesicle trafficking · correlation 0.92
- Membrane trafficking · correlation 0.91
- NF-kB regulation · correlation 0.90
- ER-Golgi Trafficking · correlation 0.89
- Proteasome/translation · correlation 0.89
- T-cell activation · correlation 0.87
- RNA processing splicing · correlation 0.84
- Proteostasis OxPhos · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.