APBB2 — Amyloid beta precursor protein binding family B member 2
APBB2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
APBB2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Tfh IL21 help B cell help | CDYL2, GDF7, HIF1A, IL21, KIAA1671, MFHAS1, MYB, PDCD1 +6 more | View in SCUBA |
| Endothelial | Endothelial Angiogenic Identity Endothelial cell development | ACTN4, ADGRL4, CAVIN1, CD93, CLEC14A, CLIC4, ESAM, MYH9 +5 more | View in SCUBA |
| Smooth muscle cells | BMP/TGF-beta response Activation | GLS, ID1, ID2, IRS2, KLF10, RND3, SEC11C, SIPA1L2 +1 more | View in SCUBA |
About the gene
| Synonyms | FE65L, FE65L1, MGC35575 |
|---|---|
| Chromosome | 4: 40810027-41216714 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Plays a role in the maintenance of lens transparency, and may also play a role in muscle cell strength (By similarity). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (By similarity). Activates transcription of APP
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.