PTPN13 — Protein tyrosine phosphatase non-receptor type 13
PTPN13 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PTPN13's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Tfh IL21 help B cell help | APBB2, CDYL2, GDF7, HIF1A, IL21, KIAA1671, MFHAS1, MYB +6 more | View in SCUBA |
| Enterocytes | Crypt antimicrobial progenitor Antibacterial | CAMK1D, CHRM3, DIAPH2, EMP2, HES1, IFITM2, LYZ, SULF2 | View in SCUBA |
| Mucosal-associated invariant T cell | Tc17 / MAIT17 Tc17 program | AHR, BAIAP2, CA10, CCR9, GFPT2, HIC1, IL17A, IL2 +5 more |
About the gene
| Synonyms | PTP-BAS, PTP-BL, PTP1E, PTPL1 |
|---|---|
| Chromosome | 4: 86594315-86815171 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Enzymes, Predicted intracellular proteins |
| Molecular function | Hydrolase, Protein phosphatase |
Function
Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling. May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.