T Cell Signaling
Gene co-expression module in CD4⁺ T cells
| Category | B cell help |
|---|---|
| Genes | 13 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 13 genes have a known function matching the annotation |
Why this annotation
Contains clear T cell signaling/costimulation genes: SH2D1A (SAP, SLAM signaling, key for T cell help to B cells/follicular help), PTPN11 (SHP2, TCR signaling), ETS1 (T cell TF), ELMO1 (Rac GEF for migration), TP53INP1 (stress/autophagy), STK17B (T cell apoptosis kinase), EFNB2. SH2D1A and ETS1 plus PTPN11 point to a T cell activation/help signaling program. SAP (SH2D1A) is central to B cell help. Moderate coherence.
Genes
CCDC6, EFNB2, ELMO1, ETS1, MYO5A, PTPN11, RABGAP1L, SFXN1, SH2D1A, SLC9A9, STK17B, TMEM70, TP53INP1
Most correlated modules
- T-cell costimulation · correlation 0.89
- Lipid Metabolism · correlation 0.87
- Immune Regulation · correlation 0.86
- CD4 Lineage Identity · correlation 0.85
- JAK-STAT Signaling · correlation 0.83
- Mitochondrial Translation · correlation 0.83
- Vesicle Trafficking Signaling · correlation 0.83
- mRNA Processing · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.