Immune Regulation
Gene co-expression module in CD4⁺ T cells
| Category | Immune regulation |
|---|---|
| Genes | 19 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 19 genes have a known function matching the annotation |
Why this annotation
Hub genes include FOXO1 (key T cell quiescence/Treg transcription factor), FAS (apoptosis/death receptor), IL10 (immunoregulatory cytokine), PTPRJ (phosphatase regulating signaling), PLAGL1, MXD4. The combination of FOXO1, FAS, IL10, and PTPRJ points to an immune regulatory / regulatory T cell program, strongly upregulated in inflammation and decreasing with treatment. This neighbors M85 which is clearly a Treg/IL1R module (FOXP3, EBI3), supporting an immune regulation interpretation.
Genes
ADAT2, AFTPH, C2CD4B, CDKL2, CPEB4, DDHD1, FAM53B, FAS, FNDC3B, FOXO1, HOXB2, IL10, MAST4, MXD4, PLAGL1, PTPRJ, SCAND1, SH3KBP1, TERF2IP
Most correlated modules
- Lipid Metabolism · correlation 0.92
- Regulatory T cell · correlation 0.90
- OxPhos & proteasome · correlation 0.87
- Mitochondrial Translation · correlation 0.86
- T Cell Signaling · correlation 0.86
- CD4 Lineage Identity · correlation 0.85
- JAK-STAT Signaling · correlation 0.85
- Interferon Response · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.