Oxidative Phosphorylation
Gene co-expression module in CD4⁺ T cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 19 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 19 genes have a known function matching the annotation |
Why this annotation
Hub genes are dominated by proteasome subunits (PSMB3, PSMC1, PSMB1, PSMA7), spliceosomal SNRPD1, and a large complement of OxPhos/mitochondrial genes (NDUFA11, NDUFC2, ATP5F1A, ATP5F1B, COX7B, COX7A2, MRPS16, MRPL21, NDUFAF8). This is a mixed biosynthetic/energy-metabolism housekeeping signature with strong electron transport chain representation. The OxPhos genes form the largest coherent functional group, but the proteasome/ribosomal components make this a general metabolic/housekeeping module. Given the dominance of NDUF/COX/ATP5 and mitochondrial ribosome genes, OxPhos best captures it. Neighbor M9 also shares OxPhos genes (ATP5MC2, COX7C, UQCRH, NDUFB5), supporting a shared metabolic activation program tracking with inflammation.
Genes
ANP32A, ATP5F1A, ATP5F1B, COX7A2, COX7B, GADD45GIP1, GNG5, MRPL21, MRPS16, NDUFA11, NDUFAF8, NDUFC2, NOP10, PSMA7, PSMB1, PSMB3, PSMC1, SNRPD1, TMEM258
Most correlated modules
- OxPhos & proteasome · correlation 0.93
- Lipid Metabolism · correlation 0.85
- Mitochondrial Translation · correlation 0.85
- mRNA Processing · correlation 0.85
- T cell activation · correlation 0.83
- OxPhos & redox · correlation 0.82
- Actin cytoskeleton · correlation 0.82
- Interferon response · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.