Leukocyte Motility
Gene co-expression module in CD4⁺ T cells
| Category | migration & adhesion |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes are cytoskeleton/motility and trafficking: MYO9B (myosin, Rho-GAP, IBD susceptibility gene), MYO1G (immune cell motility myosin), HSH2D (hematopoietic SH2 adaptor, T cell activation), LRP12, NBEAL2, TCIRG1 (V-ATPase). MYO9B and MYO1G are well-documented leukocyte migration/cytoskeletal regulators; MYO9B is an established IBD risk locus. Strong inflammation association. Cytoskeletal/migration program.
Genes
ATP2A3, HSH2D, LRP12, LZTFL1, MYO1G, MYO9B, NBEAL2, PPARG, TBC1D31, TCIRG1
Most correlated modules
- CD4 Lineage Identity · correlation 0.93
- Vesicle Trafficking Signaling · correlation 0.90
- Mitochondrial Translation · correlation 0.88
- Lipid Metabolism · correlation 0.82
- Interferon response · correlation 0.81
- Immune Regulation · correlation 0.78
- Membrane Trafficking · correlation 0.77
- JAK-STAT Signaling · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.