mRNA Splicing Processing
Gene co-expression module in CD4⁺ T cells
| Category | RNA processing |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 16 genes have a known function matching the annotation |
Why this annotation
Dominated by RNA processing/splicing and translation factors (CCNL1, PCF11, DDX5, SRSF7, EIF4A2, EIF5) plus immune GTPases (GIMAP2), BTN3A1. The hub neighborhood is RNA processing/transcription elongation (CCNL1, PCF11) and splicing (SRSF7, DDX5). Best classified as RNA processing module.
Genes
ANXA2R, APOL3, BTN3A1, CCNL1, CHCHD7, CMPK1, DDX5, EIF4A2, EIF5, GIMAP2, GRPEL1, PCF11, SRSF7, TMEM273, YIPF5, ZNF394
Most correlated modules
- AKT survival signaling · correlation 0.72
- Metabolic reprogramming · correlation 0.71
- RNA processing · correlation 0.64
- Cytotoxic Effector CD4 · correlation 0.60
- Mixed Metabolic Ambient · correlation 0.60
- mRNA Splicing Factors · correlation 0.58
- Activated Effector ISG · correlation 0.56
- Heat Shock Response · correlation 0.47
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.