ING1 — Inhibitor of growth family member 1
ING1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ING1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Metabolic reprogramming Housekeeping | ATG16L2, ATP1A1, CCNYL1, CSKMT, EIF1AY, FAM241A, HMGCS1, KLF10 +12 more | View in SCUBA |
| Fibroblasts | Integrated Stress Response Stress | ATF4, BAIAP2, DNAJB6, EIF4A3, EIF5, FSCN1, HSP90AB1, HSPD1 +9 more | View in SCUBA |
| Glial cells | DNA Damage Response Stress | BRD2, FAM53C, GADD45B, IER5, NFKBIZ, PABPC1, SRSF3, TUBB4B +1 more | View in SCUBA |
| Mucosal-associated invariant T cell | AP-1 Immediate Early Stress | AMD1, BRD2, CITED2, CSKMT, FUS, GADD45B, GADD45G, H2AX +17 more |
About the gene
| Synonyms | p24ING1c, p33, p33ING1, p33ING1b, p47, p47ING1a |
|---|---|
| Chromosome | 13: 110712736-110723339 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Biological process | Cell cycle |
Function
Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.