SLC1A5 — Solute carrier family 1 member 5
SLC1A5 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SLC1A5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Metabolic reprogramming Housekeeping | ATG16L2, ATP1A1, CCNYL1, CSKMT, EIF1AY, FAM241A, HMGCS1, ING1 +12 more | View in SCUBA |
| CD8⁺ T cells | RNA Processing Mixed RNA processing & translation | AIP, CALM1, EZR, FUBP1, HNRNPA2B1, HNRNPH3, LCP1, LRRFIP1 +8 more | View in SCUBA |
| Endothelial | Inflammatory Stress Response Stress | CRK, DLC1, GCLM, IFT20, KRAS, ODC1, SBDS, SERP1 +7 more | View in SCUBA |
| Goblet cells | ER Chaperone Glycosylation Protein processing & ER | ANG, ATP6V1G1, CD63, FKBP2, NANS, OST4, PPIC, RABAC1 +4 more | View in SCUBA |
| Innate lymphoid cells | ILC3 identity Differentiation | BHLHE40, BRD4, CASK, CITED2, GLUL, GNAS, HECA, IGFBP7 +19 more | View in SCUBA |
| Macrophages | Macrophage Proliferation Cell cycle | ALDH16A1, ARL6IP4, BIN2, BRI3BP, CCDC112, CCP110, CD33, CD36 +15 more | View in SCUBA |
| Mucosal-associated invariant T cell | NF-κB Effector Activation Inflammation | ADGRE5, BCL2A1, CCL20, CCL3, CCL3L3, CCL4, CCL4L2, DUSP10 +10 more |
About the gene
| Synonyms | AAAT, ASCT2, M7V1, RDRC |
|---|---|
| Chromosome | 19: 46774883-46788594 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Host cell receptor for virus entry, Receptor |
| Biological process | Amino-acid transport, Antiport, Host-virus interaction, Symport, Transport |
Function
Sodium-coupled antiporter of neutral amino acids. In a tri- substrate transport cycle, exchanges neutral amino acids between the extracellular and intracellular compartments, coupled to the inward cotransport of at least one sodium ion. The preferred substrate is the essential amino acid L- glutamine, a precursor for biosynthesis of proteins, nucleotides and amine sugars as well as an alternative fuel for mitochondrial oxidative phosphorylation. Exchanges L-glutamine with other neutral amino acids such as L-serine, L-threonine and L-asparagine in a bidirectional way. Provides L-glutamine to proliferating stem and activated cells driving the metabolic switch toward cell differentiation. The transport cycle is usually pH-independent, with the exception of L-glutamate. Transports extracellular L-glutamate coupled to the cotransport of one proton and one sodium ion in exchange for intracellular L-glutamine counter-ion. May provide for L-glutamate uptake in glial cells regulating glutamine/glutamate cycle in the nervous system. Can transport D-amino acids. Mediates D-serine release from the retinal glia potentially affecting NMDA receptor function in retinal neurons. Displays sodium- and amino acid-dependent but uncoupled channel-like anion conductance with a preference SCN(-) >> NO3(-) > I(-) > Cl(-) (By similarity). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development. (Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114. (Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus. (Microbial infection) Acts as a cell surface receptor for type D simian retroviruses
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.