Nuclear RNA Splicing
Gene co-expression module in CD8⁺ T cells
| Category | RNA processing & translation |
|---|---|
| Genes | 14 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes: SRRM1 (splicing coactivator), HNRNPD (AU-rich element RNA binding), CBX3 (HP1-gamma, heterochromatin), XRCC5 (Ku80, DNA repair), HNRNPR, HNRNPA3 (RNA binding), PSMD1 (proteasome), DNAJC8 (chaperone), PGP (phosphoglycolate phosphatase), MAZ (transcription factor), SNRPD3 (snRNP spliceosome), TPR (nuclear pore), THRAP3 (transcriptional coregulator), PPIG (peptidyl-prolyl isomerase). Core coherence, all core/strong memberships. Dominated by splicing (SRRM1, HNRNPD, HNRNPR, HNRNPA3, SNRPD3), chromatin (CBX3), and DNA repair (XRCC5). This is a tight nuclear RNA processing and chromatin maintenance module. The HNRNP family members and spliceosome components are well-represented, with chromatin/repair genes adding a DNA/chromatin regulation flavor.
Genes
CBX3, DNAJC8, HNRNPA3, HNRNPD, HNRNPR, MAZ, PGP, PPIG, PSMD1, SNRPD3, SRRM1, THRAP3, TPR, XRCC5
Most correlated modules
- Epigenetic Chromatin Maintenance · correlation 0.96
- RNA Processing Mixed · correlation 0.95
- Proteostasis Translation · correlation 0.94
- OxPhos & Proteasome · correlation 0.93
- Chromatin RNA Processing · correlation 0.92
- Pre-mRNA Splicing · correlation 0.92
- Nucleocytoplasmic Transport · correlation 0.92
- S-phase Chromatin Replication · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.