UBE2D2 — Ubiquitin conjugating enzyme E2 D2
UBE2D2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
UBE2D2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Effector Immune Activation Immune regulation | ABI3, APBB1IP, ASB2, BUB3, CALCOCO2, CASP4, COMMD7, CTSD +7 more | View in SCUBA |
| CD8⁺ T cells | Rho GTPase Cytoskeletal Cytoskeletal | ARHGDIA, BUD31, CYB5B, MORF4L1, PIN1, POLR2G, PPP4C, PSMB7 +5 more | View in SCUBA |
| Gamma-delta T cells | RNA Splicing Nuclear RNA processing & translation | ATRAID, BABAM2, C7orf50, CIB1, CSNK2A1, FUNDC2, GOLGA8A, GOLGA8B +10 more | |
| Innate lymphoid cells | ILC1 Inflammatory Activation Inflammation | ALOX5AP, CNOT7, COMMD10, ELAVL1, FKBP8, FNTA, IFI27L2, IL32 +11 more | View in SCUBA |
| Macrophages | RAS-MAPK Signaling Housekeeping | ARF4, ATG12, CAMTA1, CDC37, CHMP4B, ETFA, GLA, HMGA1 +26 more | View in SCUBA |
About the gene
| Synonyms | UBC4, UbcH5B |
|---|---|
| Chromosome | 5: 139526431-139628434 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transporters |
| Molecular function | Transferase |
| Biological process | Ubl conjugation pathway |
Function
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-48'- linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and SQSTM1 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by RIGI in response to viral infection. Essential for viral activation of IRF3.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.