SLC25A11 — Solute carrier family 25 member 11
SLC25A11 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SLC25A11's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Rho GTPase Cytoskeletal Cytoskeletal | ARHGDIA, BUD31, CYB5B, MORF4L1, PIN1, POLR2G, PPP4C, PSMB7 +5 more | View in SCUBA |
| Gamma-delta T cells | Cellular Homeostasis Housekeeping | ANAPC11, BANF1, CALM3, CBX3, CBX5, COMMD4, DPM2, DUT +21 more | |
| Innate lymphoid cells | Mitochondrial Metabolism Mitochondrial & OxPhos | ACTR10, ANP32A, APOL3, ATP6V1E1, ECHS1, ERCC1, ETFB, GLRX3 +12 more | View in SCUBA |
| Macrophages | Mitochondrial Biogenesis Mitochondrial & OxPhos | AIMP1, ATP5F1D, ATP5MC1, C1QBP, CCT2, CCT3, CCT7, CHCHD1 +38 more | View in SCUBA |
About the gene
| Synonyms | OGC, SLC20A4 |
|---|---|
| Chromosome | 17: 4937130-4940053 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters |
| Biological process | Antiport, Lipid transport, Transport |
Function
Catalyzes the transport of 2-oxoglutarate (alpha- oxoglutarate) across the inner mitochondrial membrane in an electroneutral exchange for malate. Can also exchange 2-oxoglutarate for other dicarboxylic acids such as malonate, succinate, maleate and oxaloacetate, although with lower affinity. Contributes to several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae. Involved in the regulation of apoptosis (By similarity). Helps protect from cytotoxic-induced apoptosis by modulating glutathione levels in mitochondria (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.