Vesicle Trafficking
Gene co-expression module in CD8⁺ T cells
| Category | Protein processing & ER |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes ARF1 (ADP-ribosylation factor driving vesicle budding), LMAN2 (ER-to-Golgi lectin cargo receptor), RAB11B (recycling endosome RAB GTPase), AP2M1 (clathrin adaptor complex mu subunit), and GNB2 (G-protein beta subunit in vesicle signaling) all point to intracellular vesicular trafficking. CDC37 is an Hsp90 co-chaperone involved in protein folding; PPP2CA (PP2A) regulates trafficking; UBB (ubiquitin) and GHITM (mitochondrial morphology/apoptosis-linked) are peripheral members. EWSR1 (RNA-binding) is the most discordant hub gene. Moderate coherence with several weak membership scores reflects the mixed protein processing/trafficking identity. As a neighbor to M27 and M8, all three modules share a constitutive housekeeping character, but M66 is uniquely enriched for membrane trafficking machinery.
Genes
AP2M1, ARF1, CDC37, EWSR1, GHITM, GNB2, LMAN2, PPP2CA, RAB11B, UBB
Most correlated modules
- Rho GTPase Cytoskeletal · correlation 0.97
- Actin Cytoskeleton Dynamics · correlation 0.94
- Proteasome Degradation · correlation 0.94
- Glycolysis Program · correlation 0.93
- Metabolic Housekeeping · correlation 0.93
- ER-Golgi Trafficking · correlation 0.92
- General Housekeeping · correlation 0.91
- RNA Splicing Complex · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.