UBE2A — Ubiquitin conjugating enzyme E2 A
UBE2A belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
UBE2A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Effector activation NFkB TCR/AP1/NFKb pathway | ADAM19, AHR, ARFGAP3, ATF5, BHLHE40, CGAS, DUSP5, ETF1 +23 more | View in SCUBA |
| CD8⁺ T cells | Rho GTPase Cytoskeletal Cytoskeletal | ARHGDIA, BUD31, CYB5B, MORF4L1, PIN1, POLR2G, PPP4C, PSMB7 +5 more | View in SCUBA |
| Gamma-delta T cells | RNA Binding/Splicing RNA processing & translation | AIMP1, ATP11B, C1orf43, CCT2, DEDD2, DGKD, ENSA, ENY2 +18 more | |
| Macrophages | Osmotic Stress Response Stress | ANKRD28, BZW1, CD109, CXCL8, CYB5R4, CYTIP, DUSP4, EMP3 +25 more | View in SCUBA |
| Mucosal-associated invariant T cell | Anti-inflammatory Homing Tissue residence | ANXA1, GPR183, NASP, PNP, TAGLN2, TUBA1C, VIM, YWHAQ |
About the gene
| Synonyms | HHR6A, HR6A, RAD6A, UBC2 |
|---|---|
| Chromosome | X: 119474802-119591083 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Chromatin regulator, Transferase |
| Biological process | DNA damage, DNA repair, Ubl conjugation pathway |
Function
E2 ubiquitin-conjugating enzyme that accepts ubiquitin from the ubiquitin-activating enzyme E1 and transfers it to a E3 ubiquitin- protein ligase. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Together with the E3 enzyme BRE1 (RNF20 and/or RNF40), plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys- 120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. Involved in mitophagy by acting as a E2 ubiquitin-conjugating enzyme for PRKN. In association with the E3 enzyme UBR4, is involved in N-end rule-dependent protein degradation. In association with the E3 ubiquitin-protein ligase complex SIFI, inhibits the mitochondrial stress response by acting as a E2 ubiquitin- conjugating enzyme for UBR4 and KCMF1.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.