Pre-mRNA Splicing
Gene co-expression module in CD8⁺ T cells
| Category | RNA processing & translation |
|---|---|
| Genes | 14 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes: HNRNPU (RNA binding), EIF3A (translation initiation), NCL (nucleolin, ribosome biogenesis), SERBP1 (mRNA stability), RBM25 (splicing), PNN (exon junction complex/splicing), RBM39 (splicing), SRRM2 (splicing coactivator), BRD2 (bromodomain chromatin), FUS (RNA processing), SRSF7 (splicing), HSPA9 (mitochondrial chaperone). Strong coherence, uniform expression. Dominated by RNA splicing regulators (RBM25, PNN, RBM39, SRRM2, FUS, SRSF7, HNRNPU) plus translation initiation (EIF3A) and nucleolar factors (NCL, SERBP1). This is a tight pre-mRNA splicing module, the clearest in the batch.
Genes
BRD2, EIF3A, FUS, HNRNPU, HSPA9, NCL, PNN, RBM25, RBM39, SERBP1, SPCS3, SRRM2, SRSF7, SSBP1
Most correlated modules
- Chromatin RNA Processing · correlation 0.94
- Nuclear RNA Splicing · correlation 0.92
- Actomyosin Motility · correlation 0.92
- RNA Processing Mixed · correlation 0.91
- Epigenetic Chromatin Maintenance · correlation 0.89
- TCR Proximal Signaling · correlation 0.84
- CD8 Effector Maturation · correlation 0.80
- Proliferating CD8 T cell · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.