SCUBA

UBXN4 — UBX domain protein 4

UBXN4 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

UBXN4's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsJAK-STAT Signaling
Immune regulation
ARHGAP30, CELF2, DDX17, DNAJC1, GSDMD, HCLS1, JAK3, MBNL1 +7 moreView in SCUBA
CD8⁺ T cellsChromatin RNA Processing
RNA processing & translation
CHD4, EIF4G2, FLNA, GNB1, MTDH, SFPQ, SRSF11, ZNF207View in SCUBA
FibroblastsER Protein Folding
Housekeeping
AHCYL1, CANX, CSNK1A1, HNRNPK, HSP90B1, JAK1, KDELR1, KTN1 +10 moreView in SCUBA
Gamma-delta T cellsDNA Damage Repair
DNA/chromatin regulation
ANKRD10, ASF1A, DDX18, DNAJC17, ENPP5, KLRC4, KLRD1, NARS1 +15 more
Goblet cellsMucin O-Glycosylation
Mucus production & secretion
ACLY, ASPH, C9orf152, CKAP4, ESRP1, FABP2, IL13RA1, PLPP5 +8 moreView in SCUBA
Innate lymphoid cellsRNA Chromatin Regulation
RNA processing & translation
ACADM, AURKAIP1, BUD23, CBX3, CMC2, COPB1, DNAJA2, DYNC1LI1 +19 moreView in SCUBA
MacrophagesRNA Splicing Regulation
Housekeeping
ABCF1, CDC42SE1, CDC5L, CDV3, CEBPZ, DNAJC7, DYNC1LI1, FGFR1OP2 +13 moreView in SCUBA
Mucosal-associated invariant T cellChemokine Receptor Migration
migration & adhesion
CCR1, CCR2, CCR5, CD47, FAM78A, KRIT1, LUC7L3, MTG1 +6 more

About the gene

SynonymsKIAA0242, UBXD2, UBXDC1
Chromosome2: 135741734-135785056
Predicted locationIntracellular, Membrane
Essential geneNo
Protein classPredicted intracellular proteins, Predicted membrane proteins
Biological processUnfolded protein response

Function

Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.