WIPF1 — WAS/WASL interacting protein family member 1
WIPF1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
WIPF1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B-cell signaling regulators B cell maturation | ACAP2, BCL2L11, CDK13, EHMT1, FNBP1, ITSN2, JAK1, KMT2A +3 more | View in SCUBA |
| CD4⁺ T cells | TCR Activation Signaling TCR/AP1/NFKb pathway | AKNA, ATP6V1A, BCL2L11, KIF20B, LAX1, NAA50, NEDD9, NPC1 +6 more | View in SCUBA |
| CD8⁺ T cells | IFN-gamma Response Inflammation | CASP3, GBP5, IFI16, IRF2, OPTN, SP100, SP140, TNFSF10 | View in SCUBA |
| Gamma-delta T cells | Hippo Pathway Signaling TCR Signaling | ADAR, ARL8B, BAZ2A, CASC3, CCDC85C, CCNK, CDC73, CDK12 +24 more | |
| Innate lymphoid cells | Lymphocyte Apoptosis Regulation Immune regulation | ANP32B, ARMCX3, CCDC69, CHD2, DHRS7, ELF1, FXYD5, GLIPR1 +14 more | View in SCUBA |
| Macrophages | ER-Golgi Trafficking Vesicular traficking | ADD1, AFTPH, AZIN1, COPA, DYNC1H1, HNRNPC, JOSD1, LCP2 +23 more | View in SCUBA |
| Mucosal-associated invariant T cell | STAT3 Cytokine Signaling Inflammation | AKAP13, AKIRIN2, AKNA, ARGLU1, BDP1, GOLGB1, H1-2, LCP1 +4 more |
About the gene
| Synonyms | WASPIP, WIP |
|---|---|
| Chromosome | 2: 174559572-174682916 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Actin-binding |
Function
Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.