SP140 — SP140 nuclear body protein
SP140 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SP140's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | BCR Ras signaling BCR/AP1/NFKb pathway | ANKRD28, CCL5, DOK3, GSTK1, GYPC, HOPX, HSH2D, ITGAM +12 more | View in SCUBA |
| CD4⁺ T cells | Effector Immune Activation Immune regulation | ABI3, APBB1IP, ASB2, BUB3, CALCOCO2, CASP4, COMMD7, CTSD +7 more | View in SCUBA |
| CD8⁺ T cells | IFN-gamma Response Inflammation | CASP3, GBP5, IFI16, IRF2, OPTN, SP100, TNFSF10, WIPF1 | View in SCUBA |
| Gamma-delta T cells | Post-transcriptional RNA Regulation RNA processing & translation | CCNG1, DHX15, FUBP1, HNRNPA3, IPO7, ITPR2, OSBPL3, PLEKHB2 | |
| Monocytes | Inflammasome Activation Innate immunity | AIM2, APOBEC3G, ARID5B, BATF3, BST2, CASP5, CD47, CNDP2 +4 more | View in SCUBA |
| Mucosal-associated invariant T cell | Lymphocyte Migration migration & adhesion | EFCAB14, IQGAP1, LNPEP, MACF1, MPRIP, OGA, PHF3, PTBP3 +4 more |
About the gene
| Synonyms | LYSP100-A, LYSP100-B |
|---|---|
| Chromosome | 2: 230203110-230313215 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | DNA-binding |
Function
Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.