UXT — Ubiquitously expressed prefoldin like chaperone
UXT belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
UXT's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Ribosome Biogenesis RNA processing & translation | BTF3, CCND3, EIF3H, EIF3L, ERP29, FBL, FXYD5, LDHB +8 more | View in SCUBA |
| Endothelial | Oxidative Phosphorylation Mitochondrial & OxPhos | ATP5F1D, ATP5MC2, ATP5PO, COX7C, ERP29, HIGD2A, HINT1, IMPDH2 +10 more | View in SCUBA |
| Gamma-delta T cells | Translation Initiation RNA processing & translation | BTF3, C12orf57, COMMD6, COX4I1, COX7C, EEF1B2, EEF1D, EEF1G +18 more | |
| Innate lymphoid cells | Protein Biogenesis & Import Protein processing & ER | ANAPC16, ATP6AP2, CD164, COMMD6, EEF1D, KLRB1, NACA, PFDN5 +6 more | View in SCUBA |
| Macrophages | Mixed Housekeeping Housekeeping | AP2M1, BAG1, CHMP4A, CISD2, COA6, CSNK2B, CYB5R3, DEGS1 +20 more | View in SCUBA |
About the gene
| Synonyms | ART-27, STAP1 |
|---|---|
| Chromosome | X: 47651796-47659180 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Activator, Chaperone, Repressor |
| Biological process | Apoptosis, Transcription, Transcription regulation |
Function
Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor AR-mediated transcription. Together with URI1, associates with chromatin to the NKX3-1 promoter region. Negatively regulates the transcriptional activity of the estrogen receptor ESR1 by inducing its translocation into the cytoplasm. May act as nuclear chaperone that facilitates the formation of the NF-kappa-B enhanceosome and thus positively regulates NF-kappa-B transcription activity. Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling. Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC. Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM. Plays a role in protecting cells against TNF- alpha-induced apoptosis by preventing the recruitment of FADD and caspase 8 to the apoptotic complex I, composed of TRADD, TRAF2 and RIPK1/RIP
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.