PKMYT1 — Protein kinase, membrane associated tyrosine/threonine 1
PKMYT1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PKMYT1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Replication Stress Checkpoint Cell cycle | ATAD5, BRCA1, CCNE2, CHEK1, DTL, EXO1, FAM111B, IFI27L1 +1 more | View in SCUBA |
| Goblet cells | Replication Fork Checkpoint Cell cycle | ATAD2, BRCA2, CENPM, CLSPN, DNAJC9, FANCI, LIG1, RRM1 | View in SCUBA |
| Hematopoietic progenitor cells | Late S-phase G2 Entry Cell cycle | ASF1B, CDC45, CDCA5, CENPM, DIAPH3, MND1, MYBL2, RAD51AP1 +1 more |
About the gene
| Synonyms | MYT1, PPP1R126 |
|---|---|
| Chromosome | 16: 2968024-2980479 |
| Predicted location | Intracellular, Membrane |
| Essential gene | Yes |
| Protein class | Enzymes, Essential proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
| Biological process | Cell cycle |
Function
Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.