SERPINB9 — Serpin family B member 9
SERPINB9 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SERPINB9's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | NF-kB activation/survival BCR/AP1/NFKb pathway | ARL4C, BCL2A1, CCR7, DDX21, GNG2, ICAM1, IRF2BPL, LMNA +9 more | View in SCUBA |
| CD4⁺ T cells | TNF/NF-kB activation TCR/AP1/NFKb pathway | BIRC3, DUSP10, GABARAPL1, HNRNPC, LUZP1, MDFIC, NSUN6, PMAIP1 +6 more | View in SCUBA |
| CD8⁺ T cells | T Cell Activation TCR Signaling | BIRC3, CRTAM, DUSP5, GADD45G, GEM, HSP90B1, HSPA5, ID3 +9 more | View in SCUBA |
| Macrophages | Anti-inflammatory Response Inflammatory | AMPD2, ARRDC2, BHLHE40, CBX4, CDKN1B, CEBPD, CITED2, DENND3 +31 more | View in SCUBA |
| Monocytes | TNF-driven Activation Inflammatory | ATP13A3, CD44, DCUN1D3, DSE, GK, IVNS1ABP, LAMB3, LITAF +3 more | View in SCUBA |
| Neutrophils | Inflammasome IL-1 Response Cytokine & chemokine secretion | CSRNP1, EGR3, G0S2, IER3, IFRD1, IL1B, IL1RN, IVNS1ABP +5 more |
About the gene
| Synonyms | CAP3, PI9 |
|---|---|
| Chromosome | 6: 2887270-2903309 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Protease inhibitor, Serine protease inhibitor |
Function
Granzyme B inhibitor
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.