PIM3 — Pim-3 proto-oncogene, serine/threonine kinase

PIM3 belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PIM3's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	NF-kB activation/survival BCR/AP1/NFKb pathway	ARL4C, BCL2A1, CCR7, DDX21, GNG2, ICAM1, IRF2BPL, LMNA +9 more	View in SCUBA
CD4⁺ T cells	NF-kB activation TCR/AP1/NFKb pathway	ABCF1, BCL2A1, BUD23, BZW2, CALR, CEBPZ, DDX21, DENND4A +21 more	View in SCUBA
CD8⁺ T cells	T Cell Activation TCR Signaling	BIRC3, CRTAM, DUSP5, GADD45G, GEM, HSP90B1, HSPA5, ID3 +9 more	View in SCUBA
Endothelial	Inflammatory Angiogenesis Endothelial cell development	FAM241A, FAM43A, KLF6, MYC, NFATC1, PHLDA1, PLEKHO2, RALGDS +7 more	View in SCUBA
Gamma-delta T cells	NF-κB Activation Inflammation	DUSP5, GADD45A, HERPUD1, IL21R, KDM6B, MAFF, NAMPT, NFKB1 +13 more
Innate lymphoid cells	ILC Survival Residency Gut residency	ARID4B, BAZ1A, BCL2A1, CD44, CSF2, CTSH, CXCL8, DUSP4 +25 more	View in SCUBA
Macrophages	Lipid-Sensing Transcriptional Lipid metabolism	ANKLE2, BAIAP2, C19orf25, C1orf52, COX19, CWC25, DEDD2, DNTTIP2 +29 more	View in SCUBA
Monocytes	Integrated Stress Response Stress	CDKN1A, CSRNP1, EIF2AK3, HBEGF, KLF10, MAFF, TIPARP	View in SCUBA
Mucosal-associated invariant T cell	NF-κB Activation Inflammation	DUSP5, DUSP8, ELL2, GABARAPL1, IRF2BP2, MAFF, NAMPT, NFKB1 +8 more
Natural Killer cells	NF-κB Activation Inflammation	ADGRE5, BCL3, BHLHE40, CSRNP1, DUSP10, NFKB1, NFKB2, NINJ1 +3 more	View in SCUBA
Pericytes	NF-κB Inflammatory Response Inflammatory	ABL2, ADAMTS9, ARL4A, BCL3, BHLHE40, FOSL2, ICAM1, KLF10 +3 more	View in SCUBA

About the gene

Chromosome	22: 49960768-49964072
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins
Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Biological process	Apoptosis, Cell cycle

Function

Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti- apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.