Late S-phase G2 Entry
Gene co-expression module in Hematopoietic progenitor cells
| Category | Cell cycle |
|---|---|
| Genes | 10 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 10 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes RAD51AP1 (RAD51-associated, HR/replication), TK1 (thymidine kinase 1, classic S-phase marker), CDCA5/Sororin (cohesion establishment, S phase), CENPM (kinetochore), ASF1B (histone chaperone, replication-coupled chromatin assembly), CDC45 (CMG helicase, replication), MYBL2/BMYB (S/G2 transcription factor), MND1 (meiotic/HR), DIAPH3 (formin, cytokinesis), PKMYT1 (kinase inhibiting CDK1, G2/M checkpoint). This module bridges S-phase replication (TK1, CDC45, ASF1B, CDCA5) and G2/M entry (PKMYT1, DIAPH3). Extremely low pct positive (0.8%) marks the most actively cycling rare cells. Consistent with a late S/G2 transition in the cell-cycle cluster neighborhood.
Genes
ASF1B, CDC45, CDCA5, CENPM, DIAPH3, MND1, MYBL2, PKMYT1, RAD51AP1, TK1
Most correlated modules
- Mitotic Spindle Checkpoint · correlation 0.94
- Replication Origin Licensing · correlation 0.90
- Mitotic Spindle · correlation 0.89
- S-phase Progression · correlation 0.86
- Mitotic Spindle · correlation 0.86
- DNA Replication S-phase · correlation 0.86
- RNA Processing Housekeeping · correlation 0.64
- Proteostasis & OxPhos · correlation 0.62
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.