Mitotic Spindle Checkpoint
Gene co-expression module in Hematopoietic progenitor cells
| Category | Cell cycle |
|---|---|
| Genes | 9 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes MAD2L1 (spindle assembly checkpoint), CENPW (kinetochore/centromere), HMGB2 (chromatin, expressed in proliferating/G2-M cells), PTTG1/Securin (anaphase inhibitor, mitosis), ZWINT (kinetochore), CKS1B (CDK regulatory subunit, mitosis/G2-M), UBE2T (ubiquitin conjugating enzyme, Fanconi pathway/mitosis), CENPF (kinetochore, G2/M), GGH (gamma-glutamyl hydrolase). The dominant theme is the spindle assembly checkpoint and kinetochore assembly, placing this module firmly in G2/M mitosis. Neighbor to M17 (mitotic spindle motors) and M66 (S phase), consistent with late cell-cycle progression.
Genes
CENPF, CENPW, CKS1B, GGH, HMGB2, MAD2L1, PTTG1, UBE2T, ZWINT
Most correlated modules
- Late S-phase G2 Entry · correlation 0.94
- DNA Replication S-phase · correlation 0.88
- S-phase Progression · correlation 0.88
- Mitotic Spindle · correlation 0.87
- Mitotic Spindle · correlation 0.87
- Replication Origin Licensing · correlation 0.86
- RNA Processing Housekeeping · correlation 0.78
- Proteostasis & OxPhos · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.