DNA Replication S-phase
Gene co-expression module in Hematopoietic progenitor cells
| Category | Cell cycle |
|---|---|
| Genes | 13 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 13 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes GINS2 (CMG replicative helicase), PCLAF/PAF15 (PCNA-associated, S phase), TYMS (thymidylate synthase, dTMP synthesis), CHEK1 (replication checkpoint kinase), PCNA (DNA clamp, replication), GMNN (geminin, replication licensing inhibitor), FEN1 (Okazaki fragment maturation), UNG (uracil-DNA glycosylase), CENPH/CENPK (centromere), CDT1 (replication licensing), RMI2 (Holliday junction dissolution), E2F1 (S-phase transcription factor). This is a tightly coherent S-phase/DNA replication initiation and execution module. Very low pct positive (5.8%) indicates this marks a small fraction of actively replicating cells. Neighbor to M67 (S-phase) and M15 (replication licensing), confirming a cluster of cell-cycle S-phase modules.
Genes
CDT1, CENPH, CENPK, CHEK1, E2F1, FEN1, GINS2, GMNN, PCLAF, PCNA, RMI2, TYMS, UNG
Most correlated modules
- Replication Origin Licensing · correlation 0.94
- S-phase Progression · correlation 0.92
- Mitotic Spindle Checkpoint · correlation 0.88
- RNA Processing Housekeeping · correlation 0.86
- Late S-phase G2 Entry · correlation 0.86
- Proteostasis & OxPhos · correlation 0.82
- Nucleotide Metabolism · correlation 0.82
- Chaperonin TRiC Complex · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.