LGMN — Legumain
LGMN belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LGMN's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Vascular Barrier Integrity migration & adhesion | APCDD1, CREB3L2, DYSF, GJA1, GRAMD1A, HDAC1, IGF2R, LAMB1 +11 more | View in SCUBA |
| Hematopoietic progenitor cells | T/NK Cell Identity Lymphcyte development | ATM, BAZ2B, CD53, LCP1, MED13L, NKG7, PREX1, RASSF2 +3 more | |
| Lymphatic endothelial | NF-κB Autophagy Regulation Immune regulation | CLIC2, GABARAPL1, NFKBIB, OSER1, PRRG4, RELB, RNF114, SQSTM1 +3 more | View in SCUBA |
| Macrophages | Endosomal Membrane Trafficking Vesicular traficking | A2M, AP1B1, ARHGAP4, ARHGEF6, ATG4C, B3GNT7, CRTAP, ETV5 +20 more | View in SCUBA |
| Monocytes | Tissue-Resident Macrophage Tissue adaptation | DAB2, ETV5, FOLR2, FRMD4A, GPNMB, ITGB5, LILRB5, LYVE1 +7 more | View in SCUBA |
About the gene
| Synonyms | LGMN1, PRSC1 |
|---|---|
| Chromosome | 14: 92703807-92748679 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase, Protease, Thiol protease |
Function
Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Also involved in MHC class I antigen presentation in cross-presenting dendritic cells by mediating cleavage and maturation of Perforin-2 (MPEG1), thereby promoting antigen translocation in the cytosol (By similarity). Required for normal lysosomal protein degradation in renal proximal tubules (By similarity). Required for normal degradation of internalized EGFR (By similarity). Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.