SCUBA

LCP1 — Lymphocyte cytosolic protein 1

LCP1 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

LCP1's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsActin Cytoskeleton
Cytoskeletal
ACTB, ACTG1, ACTR3, ARPC1B, ARPC2, ARPC4, ARPC5, BRK1 +14 moreView in SCUBA
CD4⁺ T cellsCell motility/adhesion
migration & adhesion
ANXA2, CCDC107, CYBA, FAM50A, GLIPR2, GRAP2, GYG1, ITM2B +14 moreView in SCUBA
CD8⁺ T cellsRNA Processing Mixed
RNA processing & translation
AIP, CALM1, EZR, FUBP1, HNRNPA2B1, HNRNPH3, LRRFIP1, MOB1A +8 moreView in SCUBA
Gamma-delta T cellsER Antigen Processing
Protein processing & ER
ACLY, ATL3, ATR, CANX, DCTN1, DDB1, ERAP1, FOXJ3 +9 more
Hematopoietic progenitor cellsT/NK Cell Identity
Lymphcyte development
ATM, BAZ2B, CD53, LGMN, MED13L, NKG7, PREX1, RASSF2 +3 more
Innate lymphoid cellsActin Cytoskeleton Dynamics
Cytoskeleton & motility
ACTN4, ALDH9A1, APBB1IP, ARHGAP10, CDC37, CXXC5, FAM136A, FERMT3 +26 moreView in SCUBA
MacrophagesER Stress UPR
Stress
ANKRD9, APEH, ARMCX6, BET1L, CALR, CCDC107, COPS2, DNAJB11 +20 moreView in SCUBA
Mucosal-associated invariant T cellSTAT3 Cytokine Signaling
Inflammation
AKAP13, AKIRIN2, AKNA, ARGLU1, BDP1, GOLGB1, H1-2, PPP4R3B +4 more
Natural Killer cellsNK Cell Activation
activation
ACTG1, ACTR2, ACTR3, CD38, LNPEP, MSN, TLN1, XPO1View in SCUBA

About the gene

SynonymsCP64, L-PLASTIN, LC64P, PLS2
Chromosome13: 46125920-46211871
Predicted locationIntracellular
Essential geneNo
Protein classCancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins
Molecular functionActin-binding

Function

Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.