TLE4 — TLE family member 4, transcriptional corepressor
TLE4 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TLE4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Hypoxia metabolic stress Stress | ARG2, ARL4D, AXIN2, BNIP3, CITED4, CNKSR2, GCA, GSTM3 +13 more | View in SCUBA |
| CD8⁺ T cells | AP-1 Early Activation TCR Signaling | BTG2, CD69, EGR1, FOS, FOSB, IER2, JUNB, LEPROTL1 +5 more | View in SCUBA |
| Gamma-delta T cells | AP-1 Immediate Early Response Stress | BRD2, CITED2, CSKMT, EGR1, EIF4A2, FRAT1, FRAT2, GADD45B +25 more | |
| Hematopoietic progenitor cells | Cytokine Feedback Signaling Inflammatory | ANKRD28, ATP8B4, BEX1, CALCOCO2, NOG, RHEX, SELL, SOCS3 +2 more | |
| Neutrophils | JAK-MAPK Signaling Inflammatory | CELF2, ENTPD1, GIT2, JAK2, MAPK1, MBNL1, SLMAP, SPTLC2 +1 more | |
| Smooth muscle cells | Notch-TGFbeta Signaling Development | AHI1, CD81, CD9, CPED1, EDIL3, FHL1, GSN, JUND +3 more | View in SCUBA |
About the gene
| Synonyms | E(spl), ESG, GRG4 |
|---|---|
| Chromosome | 9: 79571773-79726882 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Repressor |
| Biological process | Transcription, Transcription regulation, Wnt signaling pathway |
Function
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity). Involved in transcriptional repression of GNRHR and enhances MSX1-mediated transcriptional repression of CGA/alpha-GSU (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.