MAD2L1 — Mitotic arrest deficient 2 like 1
MAD2L1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MAD2L1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Cell Cycle Proliferation Cell cycle | ALYREF, ANP32E, BCL2L12, BIRC5, BUB3, CENPW, CEP55, CKS1B +4 more | View in SCUBA |
| CD8⁺ T cells | CDK1-Aurora Kinase Mitosis Cell cycle | AURKB, BIRC5, CCNA2, CDK1, CDKN3, CKS1B, KIF22, KIFC1 +2 more | View in SCUBA |
| Endothelial | Mitotic Spindle Cell cycle | ASPM, CCNB1, CDK1, CENPE, CENPF, CKAP2, KIF20B, KNSTRN +14 more | View in SCUBA |
| Gamma-delta T cells | Mitosis Execution Cell cycle | ASF1B, BUB1, CDCA8, CENPE, CENPF, CKS1B, EZH2, MKI67 +12 more | |
| Hematopoietic progenitor cells | Mitotic Spindle Checkpoint Cell cycle | CENPF, CENPW, CKS1B, GGH, HMGB2, PTTG1, UBE2T, ZWINT | |
| Macrophages | S-phase DNA Replication Cell cycle | ATAD2, ATAD5, BARD1, BRCA1, CENPK, CENPM, CENPU, CLSPN +31 more | View in SCUBA |
About the gene
| Synonyms | HSMAD2, MAD2 |
|---|---|
| Chromosome | 4: 120055623-120066858 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Essential proteins, Plasma proteins, Predicted intracellular proteins |
| Biological process | Cell cycle, Cell division, Mitosis |
Function
Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. In the closed conformation (C-MAD2) forms a heterotetrameric complex with MAD1L1 at unattached kinetochores during prometaphase, the complex recruits open conformation molecules of MAD2L1 (O-MAD2) and then promotes the conversion of O-MAD2 to C-MAD2. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.