Mitotic Spindle
Gene co-expression module in Hematopoietic progenitor cells
| Category | Cell cycle |
|---|---|
| Genes | 10 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 10 of 10 genes have a known function matching the annotation |
Why this annotation
All top hub genes are canonical mitotic cell cycle regulators: BIRC5 (survivin, mitotic checkpoint/cytokinesis), CDKN3 (CDK phosphatase, G2/M), CDC20 (APC/C activator, mitotic exit), HMMR (spindle assembly), DLGAP5 (spindle/kinetochore), TROAP (astral microtubule organization), CEP55 (cytokinesis), MKI67 (proliferation marker), CCNB2 (cyclin B2, M-phase), TPX2 (spindle assembly factor). The module is core coherent with very low mean expression and 1.1% positivity, consistent with a rare actively dividing cell population. Uniform expression across subsets reflects rare cycling HPCs distributed across subsets rather than contamination. This is a tightly defined mitotic/G2-M cell cycle program.
Genes
BIRC5, CCNB2, CDC20, CDKN3, CEP55, DLGAP5, HMMR, MKI67, TPX2, TROAP
Most correlated modules
- Mitotic Spindle · correlation 0.97
- Mitotic Spindle Checkpoint · correlation 0.87
- Late S-phase G2 Entry · correlation 0.86
- S-phase Progression · correlation 0.70
- Replication Origin Licensing · correlation 0.65
- DNA Replication S-phase · correlation 0.61
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.