GGH — Gamma-glutamyl hydrolase
GGH belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GGH's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Mitotic Spindle Cell cycle | ASF1B, CENPN, DDX39A, DTYMK, HMGB2, HMGN2, LMNB1, STMN1 +3 more | View in SCUBA |
| Endothelial | Mitotic Cell Cycle Cell cycle | ANP32E, BIRC5, CENPN, CENPW, CKS1B, DTYMK, PRR11, PTTG1 +3 more | View in SCUBA |
| Hematopoietic progenitor cells | Mitotic Spindle Checkpoint Cell cycle | CENPF, CENPW, CKS1B, HMGB2, MAD2L1, PTTG1, UBE2T, ZWINT | |
| Macrophages | S-phase DNA Replication Cell cycle | ATAD2, ATAD5, BARD1, BRCA1, CENPK, CENPM, CENPU, CLSPN +31 more | View in SCUBA |
About the gene
| Synonyms | GATD10 |
|---|---|
| Chromosome | 8: 63014881-63039407 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase |
Function
Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.