Megakaryocyte Commitment
Gene co-expression module in Hematopoietic progenitor cells
| Category | Myeloid development |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 10 genes have a known function matching the annotation |
Why this annotation
The module is anchored by canonical megakaryocyte/platelet markers: ITGA2B (GPIIb, megakaryocyte surface receptor), RGS18 (regulates Gi signaling in platelets/megakaryocytes), MPIG6B (megakaryocyte/platelet immunoreceptor), and SELP (P-selectin stored in alpha granules). PRKAR2B encodes a PKA regulatory subunit active in platelet signaling, PPP1R14A regulates myosin phosphatase in platelets, and RGS10 modulates platelet activation. ARHGAP6 participates in cytoskeletal remodeling during megakaryocyte maturation. CLU (clusterin) is expressed in megakaryocytes. Neighbor M55 is an even more terminal platelet biogenesis module, supporting megakaryocyte commitment identity here.
Genes
ARHGAP6, C2orf88, CLU, ITGA2B, MPIG6B, PPP1R14A, PRKAR2B, RGS10, RGS18, SELP
Most correlated modules
- Platelet Biogenesis · correlation 0.77
- Oxidative Stress Survival · correlation 0.59
- Erythroid Differentiation · correlation 0.52
- Erythro-Megakaryocytic Development · correlation 0.48
- HSC Stemness Program · correlation 0.45
- Erythroid Progenitor Program · correlation 0.42
- Erythroid Maturation Signaling · correlation 0.37
- Mature Erythrocyte · correlation 0.30
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.