SCUBA

YBX3 — Y-box binding protein 3

YBX3 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

YBX3's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsNaive B cell
B cell maturation
ABCB1, ABCB4, BTLA, C1orf162, CD200, COL19A1, DSP, FCER2 +15 moreView in SCUBA
EndothelialNotch Arterial Identity
Endothelial cell development
ADAMTS1, ARID5A, BTG1, BTG2, CRIP1, DLL4, EFNA1, EFNB2 +14 moreView in SCUBA
FibroblastsIntegrated Stress Response
Stress
ATF4, BAIAP2, DNAJB6, EIF4A3, EIF5, FSCN1, HSP90AB1, HSPD1 +9 moreView in SCUBA
Gamma-delta T cellsHeat Stress Apoptotic
Stress
AMD1, DBF4, DNAJB9, DUSP2, IER5, NFKBIB, NINJ1, PHLDA1 +5 more
Goblet cellsStress Chromatin Remodeling
chromatin regulation & transcription
ETS2, GADD45A, KDM6B, PMAIP1, SDC4, SOX9, ZBTB7A, ZFAND5 +1 moreView in SCUBA
Hematopoietic progenitor cellsMetabolic Housekeeping
Housekeeping
CRYGD, EBPL, HINT1, HSPB1, LSM7, PCBD1, PPA1, TALDO1
MacrophagesEarly response genes
Inflammatory
ATF3, BAG3, BTG2, CGAS, DNAJA1, DNAJA4, DNAJB1, DNAJB4 +39 moreView in SCUBA
Smooth muscle cellsCytoskeletal trafficking kinases
Cytoskeletal
AMIGO2, CACNA1C, CDC14B, DHRS3, IQSEC1, KIF1C, LYSMD2, MAPKAPK3 +6 moreView in SCUBA

About the gene

SynonymsCSDA, CSDA1, dbpA, ZONAB
Chromosome12: 10699089-10723323
Predicted locationIntracellular
Essential geneNo
Protein classPredicted intracellular proteins, Transcription factors
Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Function

Binds to the GM-CSF promoter. Seems to act as a repressor. Also binds to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression (By similarity)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.