NK Cytotoxic Regulation
Gene co-expression module in Innate lymphoid cells
| Category | Cytotoxicity |
|---|---|
| Genes | 38 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include SLFN5 (Schlafen family, interferon-stimulated, antiviral/antiproliferative), ARHGAP30 (Rho GAP, immune cell signaling), TBC1D10C (Rab GAP, also known as EPI64C, regulates TCR/NK signaling), CTSC (cathepsin C, serine protease activator, critical for granzyme/perforin activation in cytotoxic lymphocytes), NKTR (NK cell triggering receptor), SMC3 (cohesin, chromosome organization), CHD9 (chromatin remodeler), LAIR1 (inhibitory NK receptor), DOCK8 (Rho GEF, NK cell migration/cytotoxicity), ICAM3 (adhesion molecule), DNMT1 (DNA methyltransferase), CLK1 (splicing kinase). CTSC is essential for activating granzymes in NK cells. NKTR is an NK-specific receptor. LAIR1 is an inhibitory NK receptor. DOCK8 is required for NK cytotoxicity. SLFN5 is interferon-stimulated. TBC1D10C regulates NK degranulation. The combination of cytotoxicity-related (CTSC, DOCK8, TBC1D10C), NK receptors (NKTR, LAIR1), and interferon response (SLFN5) suggests an NK cytotoxic/immune regulatory program. The module is moderately coherent with uniform expression.
Genes
ARHGAP30, BIN2, CAPN12, CHD9, CLK1, CTSC, CYB5B, DDX27, DNMT1, DOCK8, EMB, GIMAP7, GTF3A, ICAM3, KANSL1, LAIR1, METTL23, MTF2, MYO1F, NDFIP1, NKTR, PARP1, PDLIM2, PHF14, PRMT2, RGS14, RRBP1, SLFN5, SMC3, SNW1, TBC1D10C, TES, TNRC6B, TRGC1, USF2, YIPF4, ZCCHC10, ZFAND6
Most correlated modules
- Transcriptional Regulation · correlation 0.89
- Centrosome & Scaffolding · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.