Mitochondrial Metabolic Housekeeping
Gene co-expression module in Innate lymphoid cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 25 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 20 genes have a known function matching the annotation |
Why this annotation
This moderate-coherence module contains a heterogeneous mix of genes. ALKBH7 (mitochondrial RNA demethylase), MRPS26 and MRPL34 (mitochondrial ribosomal subunits), COQ8A (coenzyme Q biosynthesis), TECR (fatty acid elongation in ER), FDFT1 (squalene synthase, cholesterol biosynthesis), DPM3 (dolichol-phosphate mannose synthase, glycosylation), OSTM1 (osteoclast stimulating factor, lysosomal), PDIA4 (ER protein disulfide isomerase), ATF6B (ER stress/UPR transcription factor), MGMT (DNA repair methyltransferase), SRSF8 (splicing factor), EIF3M (translation initiation), MAF1 (RNA Pol III repressor), BCAS1 (myelination-associated). The module combines mitochondrial, ER, and metabolic programs loosely. The ILC1 enrichment is moderate (2.1–3.0x). The strongest coherent sub-theme is mitochondrial/metabolic housekeeping with ER components. Given the mix of mitochondrial ribosomal genes, OxPhos-related (COQ8A, ALKBH7), and ER/lipid metabolism genes, this is best classified as a mixed metabolic/mitochondrial housekeeping module.
Genes
ALKBH7, ATF6B, BCAS1, COQ8A, DDT, DNAJC4, DPM3, EIF3M, FDFT1, GGCT, MAF1, MGMT, MOB2, MRPL34, MRPS21, MRPS26, NDUFA10, OLA1, OSTM1, PDIA4, PEF1, SRSF8, TCEAL8, TECR, TMEM141
Most correlated modules
- Oxidative Phosphorylation · correlation 0.97
- Actin Cytoskeletal Regulation · correlation 0.95
- Mitochondrial OxPhos · correlation 0.95
- ILC1 Lymphocyte Signaling · correlation 0.93
- ILC Transcription Factor Program · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.