MAF1 — MAF1 homolog, negative regulator of RNA polymerase III
MAF1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MAF1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Protein/ER secretory machinery Protein processing & ER | ACTR2, ATP5IF1, ATP5ME, BAZ1B, CMC2, CNPY2, COMMD3, COPZ1 +16 more | View in SCUBA |
| Gamma-delta T cells | ER Protein Biogenesis Protein processing & ER | AUP1, BAZ1B, DNAJC1, EMC10, EML3, FAM32A, FRG1, GLUD1 +10 more | |
| Innate lymphoid cells | Mitochondrial Metabolic Housekeeping Mitochondrial & OxPhos | ALKBH7, ATF6B, BCAS1, COQ8A, DDT, DNAJC4, DPM3, EIF3M +16 more | View in SCUBA |
| Macrophages | Mixed Housekeeping Housekeeping | AP2M1, BAG1, CHMP4A, CISD2, COA6, CSNK2B, CYB5R3, DEGS1 +20 more | View in SCUBA |
| Smooth muscle cells | Basal Metabolic Housekeeping Housekeeping | ARPC2, C11orf58, C1orf43, C4orf3, CNBP, COX17, GUK1, HNRNPDL +6 more | View in SCUBA |
About the gene
| Synonyms | DKFZp586G1123 |
|---|---|
| Chromosome | 8: 144104461-144107611 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Plays a role in the repression of RNA polymerase III-mediated transcription in response to changing nutritional, environmental and cellular stress conditions to balance the production of highly abundant tRNAs, 5S rRNA, and other small non-coding RNAs with cell growth and maintenance. Also plays a key role in cell fate determination by promoting mesorderm induction and adipocyte differentiation (By similarity). Mechanistically, associates with the RNA polymerase III clamp and thereby impairs its recruitment to the complex made of the promoter DNA, TBP and the initiation factor TFIIIB. When nutrients are available and mTOR kinase is active, MAF1 is hyperphosphorylated and RNA polymerase III is engaged in transcription. Stress-induced MAF1 dephosphorylation results in nuclear localization, increased targeting of gene-bound RNA polymerase III and a decrease in the transcriptional readout. Additionally, may also regulate RNA polymerase I and RNA polymerase II- dependent transcription through its ability to regulate expression of the central initiation factor TBP.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.