Endosomal Trafficking
Gene co-expression module in Innate lymphoid cells
| Category | Protein processing & ER |
|---|---|
| Genes | 20 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 20 genes have a known function matching the annotation |
Why this annotation
RAB14 (endosomal Rab GTPase), VPS4B (ESCRT/endosomal sorting), CLINT1 (clathrin interactor/endocytic trafficking), and ARL14EP (ARF-like GTPase effector) point to endosomal/vesicular trafficking. U2SURP and ZRANB2 contribute RNA splicing components, ESF1 rRNA processing, and ZC3H13 m6A RNA methylation. MDM4 and REV3L add DNA repair. Moderate coherence with predominantly weak memberships indicates a mixed module. The endosomal trafficking genes are the most coherent functional cluster.
Genes
ARL14EP, CCDC90B, CLINT1, ESF1, MDFIC, MDM4, MPHOSPH8, NRIP1, NSA2, ORMDL1, PTPRE, RAB14, REV3L, RSBN1L, TMCO1, TTC14, U2SURP, VPS4B, ZC3H13, ZRANB2
Most correlated modules
- Golgi RNA Processing · correlation 0.94
- Splicing & Transcription · correlation 0.91
- Pre-mRNA Splicing · correlation 0.90
- Centrosome & Scaffolding · correlation 0.90
- Innate Immune Activation · correlation 0.89
- Pyruvate Metabolism · correlation 0.89
- IFN-gamma Response · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.