ZC3H13 — Zinc finger CCCH-type containing 13
ZC3H13 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ZC3H13's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Rho GTPase Signaling Cytoskeletal | APOBR, ARHGEF3, ATP6V1H, BRCC3, CD46, CNDP2, CYB5R4, DCTN5 +14 more | |
| Innate lymphoid cells | Endosomal Trafficking Protein processing & ER | ARL14EP, CCDC90B, CLINT1, ESF1, MDFIC, MDM4, MPHOSPH8, NRIP1 +11 more | View in SCUBA |
| Lymphatic endothelial | Innate Immune Activation Immune regulation | CD46, CLTC, CRIM1, EIF2AK2, ENSA, FEZ2, GSN, PDLIM3 +9 more | View in SCUBA |
| Macrophages | mRNA Splicing Processing Housekeeping | AP3D1, BAZ1B, CCDC47, CHTOP, CTCF, EIF1AX, EIF3A, HDLBP +29 more | View in SCUBA |
About the gene
| Synonyms | DKFZp434D1812, KIAA0853, Xio |
|---|---|
| Chromosome | 13: 45954465-46052759 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | Developmental protein |
| Biological process | mRNA processing, mRNA splicing |
Function
Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.