PSMA6 — Proteasome 20S subunit alpha 6
PSMA6 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PSMA6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Mitochondrial ETC Mitochondrial & OxPhos | COX7B, HMGB1, HMGN1, HMGXB4, LSM5, NDUFB6, RANGRF, RBM17 +5 more | |
| Innate lymphoid cells | Mitochondrial Organization Mitochondrial & OxPhos | ARL5A, ATP5MJ, ATP5MK, BBLN, C18orf32, CIAO2B, CYRIB, EEF1G +21 more | View in SCUBA |
| Macrophages | Integrated Stress Response Stress | AKAP17A, ANKHD1, APBB3, C15orf39, CSF2RA, DDIT3, DDX39B, EMD +17 more | View in SCUBA |
| Natural Killer cells | Histone Variant Remodeling DNA regulation & transcription | ARF5, C17orf49, DDOST, GNB2, H2AX, H2AZ1, H2AZ2, IFT25 +2 more | View in SCUBA |
About the gene
| Synonyms | IOTA, MGC22756, MGC2333, MGC23846, p27K, PROS27 |
|---|---|
| Chromosome | 14: 35278633-35317493 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Enzymes, Essential proteins, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
Function
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin- independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.