SUMO3 — Small ubiquitin like modifier 3
SUMO3 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SUMO3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Interferon response Anti-viral | ACTN4, CAPZA1, CHMP4A, CHMP5, EFHD2, IL12RB1, LSP1, PARP14 +7 more | View in SCUBA |
| Endothelial | Lysosomal Autophagy Program Stress | ABCD4, AKR1A1, ASPH, CD63, CFI, EBP, GNS, MAP1LC3A +4 more | View in SCUBA |
| Gamma-delta T cells | snRNP Splicing RNA processing & translation | CHCHD2, DAZAP1, GAPDH, GIT1, GUK1, HDGF, ILF2, LAMTOR5 +16 more | |
| Innate lymphoid cells | RNA Processing & Proteostasis RNA processing & translation | ATP5PD, CIRBP, COPS6, DPY30, MORF4L1, MYDGF, PDIA6, PNISR +5 more | View in SCUBA |
| Macrophages | Glycolytic Metabolism Housekeeping | ARL1, ARPC5, ATP5PB, ATRAID, C4orf3, CALM1, CAPZA2, CHMP5 +30 more | View in SCUBA |
About the gene
| Synonyms | SMT3A, SMT3H1 |
|---|---|
| Chromosome | 21: 44805617-44818779 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Biological process | Ubl conjugation pathway |
Function
Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. Plays a role in the regulation of sumoylation status of SETX.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.