RNA Splicing Processing
Gene co-expression module in Innate lymphoid cells
| Category | RNA processing & translation |
|---|---|
| Genes | 25 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 25 genes have a known function matching the annotation |
Why this annotation
This module has strong coherence. Hub genes include NDUFA4 (NADH dehydrogenase/complex I subunit, OxPhos), LSM3 (Sm-like protein, RNA splicing/processing), SRP9 (signal recognition particle, ER targeting), CHMP2A and CHMP4A (ESCRT-III components, multivesicular body/endosomal sorting), DYNC1I2 (dynein intermediate chain, cytoplasmic dynein/motor), SF3B6 (splicing factor), RBX1 (SCF E3 ubiquitin ligase), SNRPB2 (spliceosome U2 snRNP), FKBP3 (FK506-binding protein, chromatin/transcription), SSR4 (translocon-associated protein, ER), SYF2 (splicing factor), UBE2N (ubiquitin-conjugating enzyme), DYNLRB1 (dynein light chain), SPCS1 (signal peptidase), DSTN (destrin/ADF, actin dynamics), CYBA (p22-phox, NADPH oxidase), NCBP2 (cap-binding protein), PSMB7 (proteasome beta subunit). The module combines RNA splicing (LSM3, SF3B6, SNRPB2, SYF2, NCBP2), ER/protein processing (SRP9, SSR4, SPCS1), ubiquitin-proteasome (RBX1, UBE2N, PSMB7), ESCRT/vesicle (CHMP2A, CHMP4A), and cytoskeletal motor (DYNC1I2, DYNLRB1, DSTN) components. The ILC1 enrichment of several genes is consistent with NK/ILC1 identity. This is a broad housekeeping/RNA processing module. The dominant theme by gene count is RNA processing/splicing.
Genes
ATP5F1C, CHMP2A, CHMP4A, CYBA, DSTN, DYNC1I2, DYNLRB1, FKBP3, LSM3, NCBP2, NDUFA4, NDUFAF8, NDUFB7, PSMB7, PSMC1, RBX1, RTF2, SF3B6, SNRPB2, SNRPF, SPCS1, SRP9, SSR4, SYF2, UBE2N
Most correlated modules
- Actin Cytoskeleton Remodeling · correlation 0.95
- Proteasome ER Proteostasis · correlation 0.95
- Mitochondrial Translation · correlation 0.95
- RNA Processing & Proteostasis · correlation 0.94
- ER-Golgi Trafficking · correlation 0.92
- Endosomal Trafficking Signaling · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.