Transcriptional Activation
Gene co-expression module in Innate lymphoid cells
| Category | DNA regulation & transcription |
|---|---|
| Genes | 18 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 18 genes have a known function matching the annotation |
Why this annotation
This moderate-coherence module with many weak hub memberships combines chromatin regulators (RYBP, MORF4L2, NASP), general transcription factors (GTF2B, PURB, ZNF131, AKIRIN1), and RNA processing factors (SFPQ, PTBP1). CHORDC1 is a chaperone co-chaperone involved in transcriptional regulation. The overall signature reflects a general transcriptional activation program supporting the immediate-early and stress responses seen in neighboring modules. The weak memberships of top hub genes indicate a mixed but related program.
Genes
AKIRIN1, CHORDC1, FAM133B, FAM53C, GOLGB1, GTF2B, IDI1, MORF4L2, NABP1, NASP, PTBP1, PURB, RYBP, SFPQ, SLC5A3, SPTY2D1, TBC1D17, ZNF131
Most correlated modules
- RNA Chromatin Regulation · correlation 0.92
- Integrated Stress Response · correlation 0.91
- Immediate Early Response · correlation 0.90
- ILC3 Transcriptional Identity · correlation 0.90
- Heat Shock Response · correlation 0.90
- NK Cytokine Signaling · correlation 0.90
- NF-κB Inflammatory Activation · correlation 0.89
- Prostaglandin-AP1 Response · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.