NF-κB Inflammatory Activation
Gene co-expression module in Innate lymphoid cells
| Category | Inflammation |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 16 genes have a known function matching the annotation |
Why this annotation
Moderate coherence, strongly enriched in res_ILC3. REL (core membership) is the c-Rel NF-κB subunit, a master regulator of inflammatory gene expression. KDM6B (core) is a histone H3K27 demethylase that opens chromatin at NF-κB target loci during inflammation. CD83 (core) is a canonical activation marker upregulated by NF-κB. HES4 is a Notch target. GADD45A and RGCC reflect stress/cell cycle checkpoint activation. VEGFA is an NF-κB target induced under inflammatory/hypoxic conditions. KDM6B+REL+CD83 form a coherent NF-κB-driven inflammatory activation axis. Strong delta_inflammation supports this interpretation.
Genes
AHI1, CD83, FAM107B, FKBP2, GADD45A, HES4, KDM6B, MRPS36, PRPF4B, RAB21, RAB8B, RASGEF1B, REL, RGCC, RNF19B, VEGFA
Most correlated modules
- Prostaglandin-AP1 Response · correlation 0.89
- Transcriptional Activation · correlation 0.89
- Cytokine-driven Activation · correlation 0.86
- NR4A Activation Response · correlation 0.86
- Immediate Early Response · correlation 0.85
- RNA Chromatin Regulation · correlation 0.85
- ILC3 Transcriptional Identity · correlation 0.79
- Heat Shock Response · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.