NR4A Activation Response
Gene co-expression module in Innate lymphoid cells
| Category | activation |
|---|---|
| Genes | 25 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 25 genes have a known function matching the annotation |
Why this annotation
Strong coherence module enriched in res_ILC3. Hub genes ZNF331, TIPARP, NR4A2, MCL1, CREM, NFE2L2, and CASP3 collectively represent an immediate-early activation and survival response. NR4A2 and CREM are canonical immediate-early transcription factors induced by TCR/cytokine signaling. TIPARP is a PARP enzyme activated downstream of NR4A/AhR. MCL1 is an anti-apoptotic BCL2 family member upregulated during activation. NFE2L2 (NRF2) mediates oxidative stress response during activation. DLL1 (Notch ligand) and GPR65 add inflammatory context. The strong delta_inflammation signal supports an inflammatory activation program in ILC3s.
Genes
ALG13, ARL4A, BCAS2, CASP3, CHMP1B, CREM, DDX24, DLL1, DNAJB9, DYNLT1, G3BP2, GPR65, HINT3, MAFF, MCL1, NFE2L2, NR4A2, PRMT9, RNF139, RNF168, SAFB2, SELENOK, TIPARP, YPEL5, ZNF331
Most correlated modules
- Prostaglandin-AP1 Response · correlation 0.94
- Integrated Stress Response · correlation 0.89
- Transcriptional Activation · correlation 0.88
- NF-κB Inflammatory Activation · correlation 0.86
- RNA Chromatin Regulation · correlation 0.86
- NK ILC Tissue Homing · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.