Integrated Stress Response
Gene co-expression module in Innate lymphoid cells
| Category | Stress |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
ATF4 is the master transcription factor of the integrated stress response (ISR) and ER stress. HERPUD1 is a direct UPR/ER stress target. DNAJB6 is a chaperone upregulated during proteotoxic/ER stress. AMD1 (polyamine synthesis) is ATF4-regulated. SRSF2, SRSF3, DDX5, HNRNPH1, RBM8A are splicing factors co-regulated with stress. EIF1 relates to translation reinitiation during ISR. CYCS (cytochrome c) suggests mitochondrial involvement. The module captures the ATF4-driven integrated stress/UPR response with co-regulated RNA processing.
Genes
AMD1, ATF4, CYCS, DDX5, DNAJB6, EIF1, GPBP1, HERPUD1, HNRNPH1, RBM8A, SRSF2, SRSF3
Most correlated modules
- Transcriptional Activation · correlation 0.91
- NR4A Activation Response · correlation 0.89
- mRNA Stability & Splicing · correlation 0.89
- RNA Chromatin Regulation · correlation 0.86
- Cytokine-driven Activation · correlation 0.84
- Heat Shock Response · correlation 0.83
- NK Cytokine Signaling · correlation 0.83
- Immediate Early Response · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.