Prostaglandin-AP1 Response
Gene co-expression module in Innate lymphoid cells
| Category | Inflammation |
|---|---|
| Genes | 21 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 21 genes have a known function matching the annotation |
Why this annotation
Strong coherence, enriched in res_ILC3. PTGS2 (COX-2, core) is the rate-limiting enzyme in prostaglandin synthesis and a hallmark of inflammatory activation. PTGER4 (core) is the EP4 prostaglandin E2 receptor, creating an autocrine/paracrine loop. FOSL2 (strong) and NR4A3 (core) are AP-1 and nuclear receptor immediate-early transcription factors that drive PTGS2 expression. CXCL2 (moderate) is an inflammatory chemokine. PDE4B (strong) regulates cAMP downstream of prostaglandin signaling. ETV3 is an ETS repressor. IRF2BP2 is a transcriptional co-repressor. The PTGS2/PTGER4/FOSL2/NR4A3 axis defines a prostaglandin-AP-1 inflammatory program. Strong delta_inflammation supports this.
Genes
ARIH1, ARL5B, CCNT1, CHD1, CXCL2, ETV3, FOSL2, IRF2BP2, JOSD1, NR4A3, PCNX4, PDE4B, PTGER4, PTGS2, RANBP2, SKIL, SPRY1, SYAP1, TCTN3, VPS37B, ZBTB1
Most correlated modules
- NR4A Activation Response · correlation 0.94
- NF-κB Inflammatory Activation · correlation 0.89
- Transcriptional Activation · correlation 0.88
- RNA Chromatin Regulation · correlation 0.86
- NK ILC Tissue Homing · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.