TRiC Chaperonin Folding
Gene co-expression module in Innate lymphoid cells
| Category | Protein processing & ER |
|---|---|
| Genes | 18 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 18 genes have a known function matching the annotation |
Why this annotation
Hub genes CCT2, CCT3, CCT4, CCT5 (all strong/core members) are subunits of the TRiC/CCT chaperonin complex, which folds actin, tubulin, and other proteins. PTGES3 (p23, Hsp90 co-chaperone), STIP1 (Hsp70/Hsp90 organizing protein), CACYBP (calcyclin-binding protein involved in ubiquitination), PSMB4/PSMD13 (proteasome) extend the chaperone-proteasome axis. EIF5A (translation factor) and NOP58 (rRNA processing) are peripheral. The CCT complex dominates with 4 subunits as top hub genes. This is a chaperonin-mediated protein folding module, neighboring the proteasome-heavy M74.
Genes
ATP6V0D1, CACYBP, CCT2, CCT3, CCT4, CCT5, EIF5A, ELOC, FAM162A, METTL5, NOL7, NOP58, PSMB4, PSMD13, PTGES3, SRA1, STIP1, TNFAIP8
Most correlated modules
- RNA Chromatin Regulation · correlation 0.94
- DNA Damage Response · correlation 0.94
- Proteasome ER Proteostasis · correlation 0.91
- RNA-binding & Splicing · correlation 0.89
- NK JAK3 Signaling · correlation 0.87
- RNA Processing & Proteostasis · correlation 0.87
- Actin Cytoskeleton Dynamics · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.