PPIG — Peptidylprolyl isomerase G
PPIG belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PPIG's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | DNA damage response DNA/chromatin regulation | ATP2B1, CENPC, DEAF1, FBXO34, HAX1, HECTD1, KMT5C, MRPL50 +7 more | View in SCUBA |
| CD8⁺ T cells | Nuclear RNA Splicing RNA processing & translation | CBX3, DNAJC8, HNRNPA3, HNRNPD, HNRNPR, MAZ, PGP, PSMD1 +5 more | View in SCUBA |
| Gamma-delta T cells | Pre-mRNA Splicing RNA processing & translation | AKAP7, ARID1A, CEP57, EIF4E, ENOSF1, GGNBP2, HERC5, HNRNPD +8 more | |
| Innate lymphoid cells | RNA-binding & Splicing RNA processing & translation | CALM1, DYNLL1, FUS, HNRNPA2B1, HNRNPAB, NCL, NUDC, SAP18 +4 more | View in SCUBA |
| Macrophages | mRNA Splicing Processing Housekeeping | AP3D1, BAZ1B, CCDC47, CHTOP, CTCF, EIF1AX, EIF3A, HDLBP +29 more | View in SCUBA |
About the gene
| Synonyms | CARS-Cyp, SCAF10, SRCyp |
|---|---|
| Chromosome | 2: 169584342-169641406 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Isomerase, Rotamase |
Function
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.