Heat Shock Chaperone
Gene co-expression module in Lymphatic endothelial
| Category | Stress |
|---|---|
| Genes | 8 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 8 genes have a known function matching the annotation |
Why this annotation
All eight genes encode molecular chaperones or co-chaperones: HSPD1 (HSP60, mitochondrial chaperonin), TCP1 and CCT4 (CCT/TRiC chaperonin complex subunits), STIP1 (HOP, HSP70-HSP90 organizing protein), AHSA1 (AHA1, HSP90 ATPase activator), FKBP4 (FKBP52, HSP90 co-chaperone), DNAJB6 (HSP40 co-chaperone), and CHORDC1 (CS domain HSP90 co-chaperone). This is an exceptionally coherent proteostasis/chaperone module representing the heat shock protein network. Neighbor context: sits alongside ISR (M48) and inflammatory modules, consistent with proteotoxic stress in inflamed lymphatic endothelium.
Genes
AHSA1, CCT4, CHORDC1, DNAJB6, FKBP4, HSPD1, STIP1, TCP1
Most correlated modules
- Notch TGF-β Endothelial · correlation 0.84
- Integrated Stress Response · correlation 0.82
- NF-κB Negative Feedback · correlation 0.80
- DNA Damage Autophagy · correlation 0.79
- Heat Shock Response · correlation 0.79
- Hypoxic Stress Response · correlation 0.77
- RNA Protein Homeostasis · correlation 0.74
- NF-κB Inflammatory Activation · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.